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The morphology of amphiphilic assembly can range from spherical micelles,vesicles or other symmetric shapes that are determined by intrinsic molecular properties and the environment.However,engineering the assembly of amphiphiles into customized shapes remains a challenge.[1]Here we report an artificial frame-guided assembly process to prepare vesicles with programmed geometries and dimensions that was inspired by the cytoskeletal structure of eukaryotic cells.As shown in Fig.1,assembled DNA frames position leading hydrophobic groups (LHGs) along the fringe of designed structures,and subsequently drive a secondary amphiphilic molecule to fill into the gaps between LHGs,resulting in the formation of guided vesicle assemblies.[2] The shape and size of vesicles are determined by designed DNA frames,thus allowing desired vesicle structures to be engineered by adopting different DNA scaffolds.