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  5. K33-linked polyubiquitination of Zap70 by E3 ligase Nrdp1 controls activation of CD8+ T cells

K33-linked polyubiquitination of Zap70 by E3 ligase Nrdp1 controls activation of CD8+ T cells

来源 :中国免疫学会第十届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：mzhou2009
【摘 要】
：
Key molecular mechanisms controlling T cell receptor (TCR) signaling remain to be fully elucidated.Here we report that Nrdp1, a ring-finger type E3 ligase, mediates TCR signaling in CD8+T cells.We dem
【作 者】
：
Mingjin Yang Taoyong Chen Xuelian Li Zhou Yu Jianli Wang Xuetao Cao 
【机 构】
：
National Key Laboratory of Medical Molecular Biology & Department of Immunology,Institute of Basic M
【出 处】
：
中国免疫学会第十届全国免疫学学术大会
【发表日期】
：
2015年10期
【关键词】
：
Nrdp1 polyubiquitination Zap70 TCR signaling 
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　　Key molecular mechanisms controlling T cell receptor (TCR) signaling remain to be fully elucidated.Here we report that Nrdp1, a ring-finger type E3 ligase, mediates TCR signaling in CD8+T cells.We demonstrate that Nrdp1 is highly and selectively expressed by nave CD8+T cells, and its deficiency significantly promotes activation and proliferation of CD8+ T cells after TCR engagement.
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