Objective Evaluate the therapy methods and clinical therapy value of cervical lesions which could not be performed with cervical conization.Methods A total of 135 cases were collected in Tianjin Central Hospital of Obstetrics and Gynecology between January 2011 to April 2014.They were with high grade cervical intraepithelial neoplasia (CIN2-3) and undiagnosed early invasive cervical cancer.In these patients, they accepted other kinds of hysterectomies because of the conditions of cervix that could not accept conization.Their clinical pathological data, effectiveness were retrospectively studied.Results Among 135 patients, 82.2% (111/135) of them received extrafascial hysterectomy (EHT),14.8% (20/135) of them received modified radical hysterectomy (MRH), 3.0% (4/135) of them received radical hysterectomy(RH).According to postoperative clinical pathological stages,82.2%(111/135)of them received appropriate treatment, 5.2% (7/135) of 135 patients received unsufficient treatment rate because of unsufficient surgery, 12.6%(17/135) of them received excessive treatment rate because of excessive surgery.The appropriate treatment rate of CIN group was 91.3%(84/92), and 62.8% (27/43) in cervical cancer group.There was a significant difference between two groups with appropriate treatment rate of surgical method (x2 =16.299, P<0.001).The appropriate treatment rate of EHT group was 96.4% (107/111), 16.7%(4/24)in MRH and RH group.There was a significant difference between two groups in appropriate treatment rate (x2 =80.449, P<0.001).Conclusion For patients with high grade CIN or undiagnosed early invasive cervical cancer but fail to be performed with cervical conization owing to their cervix, EHT can be the first clinical choice for avoiding unsufficient and excessive treatment.