【摘 要】
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Objective: The study aimed to optimize the time-density curve (TDC) of dynamic contrast-enhanced computed tomography (CECT) for separation of the pulmonary and systematic circulation of rabbit lung. M
【机 构】
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Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508,
【出 处】
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中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
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Objective: The study aimed to optimize the time-density curve (TDC) of dynamic contrast-enhanced computed tomography (CECT) for separation of the pulmonary and systematic circulation of rabbit lung. Materials and Methods: After approval of our centers Animal Care and Use Committee, 40 New Zealand white rabbits were randomly divided into 4 groups according to injection rate and volume of contrast material: group 1 (rate of 1.5 ml/s and volume of 1.0 ml), group 2 (rate of 1.5 ml/s and volume of 2.0 ml), group 3 (rate of 2.0 ml/s and volume of 1.0 ml) and group 4 (rate of 2.0 ml/s and volume of 2.0 ml). TDCs of the pulmonary and aortic artery were generated following dynamic CECT, and parameters including maximum enhancement CT value of pulmonary artery (PA-max), time to PA-max (Tpa-max), slope of PA-max (Spamax), maximum enhancement CT value of aortic artery (AA-max) and time difference to peak of PA-max and AA-max (Tpa-aa) were analyzed via a Kruskal-Wallis test. Results: TDCs of the pulmonary and systematic circulation were in bell shape. PA-max of group 2 was higher than that of group 1 and group 3(p=0.004151;0.000656); Spa-max of group 2 was higher than that of group 1 (p=0.000408,α=0.004167); AAmax of group 2 was higher than that of group 3 (p=0.000749); Tpa-aa of group 2 was higher than that of the other groups, but there was no significant difference (p=0.4975). Conclusion: TDC of the group 2, with contrast material injection rate of 1.5 ml/s and volume of 2.0 ml, was more suitable for separation of the pulmonary from systematic circulation of rabbit lung.
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