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Objective To illuminate the combination effects of 15 groups of antimicrobial combinations that combined with each other by 6 kinds of common antibiotics (A-Amoxicillin, C-Clarithromycin,M-Metronidazole, L-Levofloxacin, T-Tetracycline, F-Furazolidone) against antibiotic resistant clinical Isolates of Helicobacter pylori in vitro, and then giving some advices for the rational choice of antibiotics to efficient combinations to solve the problem of AntibioticResistant Helicobacter pylori in clinic.