Purpose: miR-34a is one of P53 inducible miRNAs, and is the most pronounced induction by DNA damage.A number of mRNAs have been proved to be direct targets of miR-34a, especially those genes which hav
The biological effects of chronic radiation exposure are far from complete.With the aim of better understanding the biological effects of chronic radiation exposure and the underlying mechanism for th
The present study aims to evaluate of the fluorescence in situ hybridization (FISH) translocations assay for retrospective dose estimation of past acute accidental exposure.
Helicase are enzymes which can catalyze the unwinding of the DNA duplex, which play important roles in almost all the nucleic acid metabolism, including DNA replication, transcription, recombination a
Salt-inducible kinase is aserine/threonine protein kinase belonging to the member of AMP-activated protein kinase subfamily.There are three isoforms, including SIK1,SIK2 and SIK3.SIK2 is specifically
Radiation-induced skin injury is a serious concern for radiation therapy.Heme oxygenase-1 (HO-1) catalyzes the heme ring into carbon monoxide (CO), free iron and biliverdin and is strongly induced by
The purpose of this study is to investigate the effect of heavy ion beams on human brain tumor cells.Two brain tumors of human origin, an ependymoblastoma (EB) with wild-type p53 and a glioblastoma (G