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  5. Effects of the compatibility of Radix Aconiti Laterlis and Radix Glycyrrhizae on the Pharmacokinetic

Effects of the compatibility of Radix Aconiti Laterlis and Radix Glycyrrhizae on the Pharmacokinetic

来源 :第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会 | 被引量 : 0次 | 上传用户：mqj1965
【摘 要】
：
A simple and sensitive high performance liquid chromatographic method coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS) was developed and validated for the analysis of aconitine, me
【作 者】
：
Hong Shen Jie Wu Ling-Ying Zhu Jun Xu Song-Lin Li 
【机 构】
：
Jiangsu Province Academy of Chinese Medicine, Jiangsu Research Center for Modern TCM Pharmaceutics P
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
【发表日期】
：
2011年3期
【关键词】
：
Aconitine Mesaconitine Hypaconitine HPLC-MS Pharmacokinetics Radix Aconiti Later 
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　　A simple and sensitive high performance liquid chromatographic method coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS) was developed and validated for the analysis of aconitine, mesaconitine and hypaconitine simultaneously in rat plasma.Based on this method, we investigated the effect of the compatibility of Radix Aconiti Laterlis and Radix Glycyrrhizae on the pharmacokinetics of the three alkaloids in Rats.The drugs of Radix Aconiti Latedis decocted singly and Radix Aconiti Laterlis and Radix Glycyrrhizae decocted together were orally administered to two groups of rats, for the same dosage of 1.5 g.kg-1 in Radix Aconiti Laterlis.
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