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Objective Previous evidences from randomized controlled trials and observational studies have suggested that FOBT-based screening could reduce the mortality of CRC.However,it was reported that the diagnostic performance of FOBT varied by anatomical sites of colorectum in some studies.Therefore,we conducted a systematic review and meta-analysis aiming at evaluating the differences of diagnostic performance of fecal occult blood tests(FOBTs)in detecting colorectal neoplasms located in the proximal versus distal colorectum.