【摘 要】
：
BACKGROUND: Selenium(Se)is one of the important antioxidants with chemoprotective and anti-carcinogenic effect.Polysaccharides from Pyracantha fortuneana(Maxim.)Li(PFPs)are reported with antioxidative
【机 构】
：
College of Medical Science,China Three Gorges University,Yichang,HuBei,443002
【出 处】
：
中国生物化学与分子生物学会2016年全国学术会议
论文部分内容阅读
BACKGROUND: Selenium(Se)is one of the important antioxidants with chemoprotective and anti-carcinogenic effect.Polysaccharides from Pyracantha fortuneana(Maxim.)Li(PFPs)are reported with antioxidative and immunoprotective activities.Whether Se-containing polysaccharides may have synergistic effect on enhancing the antioxidant and immune activities? Polysaccharides from Seenriched P.fortuneana(Se-PFPs)with hepatoprotective effects have been reported in our previous study,however,the antimutagenic effects are uncertain.METHODS: The antimutagenicity of Se-PFPs in mice was evaluated using micronucleus assay,whose mechanism was further analyzed in comparison with those of PFPs or Se alone or Se+PFPs.RESULTS: Our results demonstrated that Se-PFPs can inhibit cyclophosphamide-induced micronucleus formation in both bone marrow and peripheral blood,enhance the activities of SOD and GPx in mice liver,and reduce the activity and expression of Cytochrome P450 1A(CYP1A)in a dose-dependent manner in mice liver.CONCLUSION: These results suggest that the antimutagenic potential of Se-PFPs may be involved in the inhibition of CYP1A activity and its expression.In addition,the antimutagenic potential of Se-PFPs is higher than that of PFPs,Se alone or Se+PFPs.
其他文献
Mesenchymal stem cells(MSCs)are promising vehicles for the delivery of anticancer agents in cancer therapy.However,the tumor targeting of loaded therapeutics is essential.Here,we explored a dual-targe
Isocitrate dehydrogenase(IDH)is a kind of crucial enzyme family in tricarboxylic acid(TCA)cycle,which convents socitric acid to α-ketoglutarate(α-KG)in mitochondria.The clinical data have shown that t
脂肪酶是一种重要的酶，它普遍存在于自然界，被广泛运用于精细化工、洗涤、医药、食品、造纸、皮革加工、纺织和饲料工业等领域，但其应用仍然受到天然脂肪酶分子的耐受性差、在应用条件下的催化活性低、新脂肪酶开发速度慢等因素的极大限制。因此，对现有脂肪酶进行分子改造使其更加符合人类的需求，成为了近几年的研究热点与难点。脂肪酶分子改造的常见方法有化学修饰、理性设计、定向进化等，其中在脂肪酶分子改造中引入偏最小二
Lung cancer is the leading cause of cancer-related deaths worldwide and is associated with a very poor outcome.Oxymatrine exerts anti-tumor effects by inducing apoptosis and inhibiting the proliferati
TBC(Tre-2/Bub2/Cdc16)域家族都是高度保守的蛋白,具有很高的同源性,TBC1D15 是TBC 家族的成员,具有特定的Rab-GAP 活性,已在鼠,人等五种中有所报道,但是其在鲨鱼中的报道至今较少。本实验主要研究条纹斑竹鲨中TBC1D15 的对Rab 蛋白的底物专一性及某些保守氨基酸位点突变后对其Rab-GAP 活性功能的影响；并与猪,人中的TBC1D15 相比较,以分析出决定TB
The mammalian selenoproteinthioredoxinreductase 1(TrxR1)is one of the most importantenzymes in redox regulation,antioxidant defense,and cellular growth.TrxR1 can catalyze efficient reduction of juglon
In the previous reports,Crocodile choline(CCL),an active compound which was obtained from Siamese Crocodile,could inhibit the growth of cancer cells.It was indicated that CCL experted anti-cancer effi
The PI3K/Akt/mTOR(PAM)signaling pathway plays a key regulatory function in cell survival,proliferation,migration,radiotherapy,and chemotherapy.PAM signaling pathway is activated in approximately 70%of
Quercitrin is a natural compound.It is extracted from the flowers of Albizzia julibrissin Durazz and is an inhibitor of calcineurin(CN).In this study,we investigated its inhibitory effects on CN,and i
"Xiebai" is a medicine-food dual purpose Chinese native medicine,commonly seen in the diet of Chinese family andtraditionally used in the treatment of multiple cardiovascular,respiratory and digestive