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  5. Activation of FcεRI in nociceptive sensory neurons by IgE immune complex is involved in pruritus in

Activation of FcεRI in nociceptive sensory neurons by IgE immune complex is involved in pruritus in

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：bbatdead
【摘 要】
：
Pruritus is a common symptom of allergic conjunctivitis.We established a mouse model of allergic conjunctivitis using oval albumin (OVA) and discovered an increased level of antigen-specific IgE in th
【作 者】
：
Fan Liu Lubin Xu Naze Chen Mo Zhou Haowu Jiang Xinhua Shen Zhiyong Chen Chunyan Li Bo Yuan Chao Ma 
【机 构】
：
Department of Anatomy, Histology and Embryology, School of Basic Medicine, Peking Union Medical Coll
【出 处】
：
The 18th Congress of the International Federation of Associa
【发表日期】
：
2014年8期
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Pruritus is a common symptom of allergic conjunctivitis.We established a mouse model of allergic conjunctivitis using oval albumin (OVA) and discovered an increased level of antigen-specific IgE in the sera of OVA-sensitized mice.Fc epsilon receptor I (FcεRI) was found to be expressed on the somata and axons of mouse trigeminal ganglion (TG) neurons and co-expressed with nociceptive neuronal markers IB4, CGRP and TRPV1.
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