PURPOSE: To observe the therapeutic effect of concentrated growth factors (CGF) on the healing process of goat condylar cartilage defect.METHODS: 3 goats on the age of 6 months (average weight=16Kg)were use.Each had bilateral condyle cartilage resected, then autologous venous blood were collected to obtain CGF.CGF was used to cover one side of the condyle cartilage defect, the other side of the condyle cartilage defect was uncovered as a control.Gross observation and histological examination were performed at 1 month after the operation.RESULTS: The condylar surface of the control side was uneven while the experimental condylar surface was smooth, covered by cartilage-like tissue.HE staining of the control side showed exposed subchondral bone, active bone resorption of osteoclasts, and inflammatory reaction.While the experimental side showed no obvious inflammatory reaction and bone resorption.The bone surface was covered of fibrous tissue.CONCLUSION: CGF can reduce inflammation and bone resorption after cartilage damage, It can also promote fibrous tissue repair to protective the subchondral bone.Supported by Research Fund of Science and Technology Commission of Shanghai Municipality (08DZ2271100, 13XD1402300), Program for Innovative Research Team of Shanghai Municipal Education Commission, Scientific Research Foundation of Ministry of Education for Returned Overseas Scholars, Research fund of the Ministry of Health public (201002017),and Shanghai Natural Science Foundation (13ZR1423500).