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  5. Novel Y-chromosomal microdeletions associated with non-obstructive azoospermia uncovered by high thr

Novel Y-chromosomal microdeletions associated with non-obstructive azoospermia uncovered by high thr

来源 :泌尿生殖肿瘤华夏医学论坛2016暨长城国际泌尿男科转化医学论坛2016 | 被引量 : 0次 | 上传用户：billdyj
【摘 要】
：
Y-chromosomal microdeletion (YCM) serves as an important genetic factor in non-obstructive azoospermia (NOA).Multiplex polymerase chain reaction (PCR) is routinely used to detect YCMs by tracing seque
【作 者】
：
Zesong Li 
【机 构】
：
Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated
【出 处】
：
泌尿生殖肿瘤华夏医学论坛2016暨长城国际泌尿男科转化医学论坛2016
【发表日期】
：
2016年8期
【关键词】
：
Y-chromosomal microdeletions (YCM) non-obstructive azoospermia (NOA) haplogroup 
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　　Y-chromosomal microdeletion (YCM) serves as an important genetic factor in non-obstructive azoospermia (NOA).Multiplex polymerase chain reaction (PCR) is routinely used to detect YCMs by tracing sequence-tagged sites (STSs) in the Y chromosome.Here we introduce a novel methodology in which we sequence 1,787 (post-filtering) STSs distributed across the entire male-specific Y chromosome (MSY) in parallel to uncover known and novel YCMs.
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