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  5. Surface modification and properties of polylactic acid nanoparticles with cell membrane mimetic coat

Surface modification and properties of polylactic acid nanoparticles with cell membrane mimetic coat

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：jayexxfu1
【摘 要】
：
Biodegradable polymeric nanoparticles are widely recognized as efficacious drug delivery vehicles.Yet, the rapid recognition and clearance of intravenously injected nanoparticles by macrophages in the
【作 者】
：
Hao-Qiang huang Li-Li Bao Peng-Fei Huang Yong-Kuan Gong 
【机 构】
：
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,Colle
【出 处】
：
International Conference on Nanoscience & Technology,China 2
【发表日期】
：
2013年3期
【关键词】
：
Nanoparticle polylactic acid phosphorylcholine controlled release surface modifi 
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　　Biodegradable polymeric nanoparticles are widely recognized as efficacious drug delivery vehicles.Yet, the rapid recognition and clearance of intravenously injected nanoparticles by macrophages in the tissues can dramatically reduce both the nanoparticle half-life and delivery to the diseased tissue.Here, we show the surface engineering of polylactic acid nanoparticles (PLA-NPs) by coating cell membrane mimetic copolymers to evade macrophage recognition.
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