A Striatal-Enriched Intronic GPCR and Its Host Gene Modulate Huntingtin Levels via cAMP-dependent bu

来源 :长三角地区神经科学论坛暨浙江省神经科学学会2014年年会 | 被引量 : 0次 | 上传用户：whywhy_why

【摘要】

：

Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder that has been used as an important model of genetically determined neurodegenerativ

【作者】

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鲁伯埙

【机构】

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复旦大学,生命科学学院

【出处】

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长三角地区神经科学论坛暨浙江省神经科学学会2014年年会

【发表日期】

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2014年9期

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Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder that has been used as an important model of genetically determined neurodegenerative diseases and proteinopathies.HD is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with the expanded polyQ stretch.While Htt is ubiquitously expressed,HD is characterized by selective neurodegeneration of the corpus striatum.

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A Striatal-Enriched Intronic GPCR and Its Host Gene Modulate Huntingtin Levels via cAMP-dependent bu

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