Objective To investigate the predictors associated with the onset of atrial fibrillation (AF) in hypertensive patients.Methods We included 233 patients with AF in hypertensive patients (mean age [60±9] years), and 190 hypertensive patients without AF (mean age [55±7] years) for a retrospective study about the clinical correlates of atrial fibrillation (AF) in hypertensive patients.The clinical data were collected and the differences between the two groups were compared.Logistic regression analysis was used to analysize the risk factors associated with atrial fibrillation in hypertensive patients.Results Univariate analysis shows that compared with the Non-AF, hypertensive patients with AF were older (p<0.001) and have higher body mass index (BMI) (p=0.019), greater echocardiography measurement of left atrial diameter (p<0.001), left ventricular diastolic diameter (p<0.001) and left ventricular systolic diameter (p<0.001), but have lower left ventricular ejection fraction (p=0.005).Uric acid (p=0.013) and creatinine (p<0.001) were higher but total cholesterol(TC) (p<0.001) and low-density lipoprotein cholesterol (LDL-C)(p<0.001) were lower in hypertensive patients with AF than hypertensive patients without AF.After multivariate logistic regression analysis, the independent predictors were age, left atrial diameter and LDL-C, among which age and left atrial diameter were positively correlated with AF in patients with hypertension (OR=1.080, 95% CI: 1.037-1.125 P=0.000、 OR=1.511, 95%CI: 1.377-1.632, P=0.000), while LDL-C was negatively correlated with it (OR=0.524 , 95%CI: 0.363-0.781, P=0.001).Conclusions Age, left atrial diameter and LDL-C were independent predictors for the onset of AF in hypertensive patients, Higher levels of LDL-C were associated with a lower incidence of AF.