Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leuke

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：aaitata

【摘要】

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【作者】

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chengwu zeng yangqiu li

【机构】

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Institute of Hematology,Medical College,Jinan University,Guangzhou

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Background Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17),which fuses PML with retinoic acid receptor alpha (RARα).Although PML-RARα is crucially important for pathogenesis and responsiveness to treatment,the molecular and cellular mechanisms by which PML-RARα exerts its oncogenic potential have not been fully elucidated.Recent reports have suggested that long non-coding RNAs (lncRNAs) contribute to the precise control of gene expression and are involved in human diseases.Little is known about the role of IncRNA in APL.

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Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leuke

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