【摘 要】
：
To observe the changes of cardiac ALDH2 in diabetic rat, especially when diabetic rat was pretreated with ALDH2 activator ethanol (EtOH).The rats were divided into 5 groups: control, diabetic rat at f
【机 构】
：
Department of Physiology,Bengbu Medical College D
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
To observe the changes of cardiac ALDH2 in diabetic rat, especially when diabetic rat was pretreated with ALDH2 activator ethanol (EtOH).The rats were divided into 5 groups: control, diabetic rat at fourth week (DM4W), eighth week (DM8W), twelfth week (DM12W) and EtOH+DM8W groups.Compared with control group, fasting blood glucose (FBG) and glycosylated hemoglobin (HbAlc) levels were increased in DM groups,but no difference about FBG.HbAlc level in DM12W group was higher than in DM4W group, and lower in EtOH+DM8W group than in DM8W group.Compared with control group, there had no changes of LVDP, HR and ±dp/dtmax in DM4W group, but decreased in DM8W and DM12W groups, and increased in EtOH+DM8W group.In DM groups, ALDH2 activity, mRNA and protein levels were reduced.With the development of diabetes,ALDH2 activity, mRNA and protein levels were further reduced.Compared with DM8W group, ALDH2 in EtOH+DM8W group were increased.Our results indicated that with the development of diabetes, the expression and activity of myocardial ALDH2 were further decreased accompanying with the decrease of ventricular function.Activation of ALDH2 can decrease diabetes induced myocardial injury.ALDH2 may be one of key endogenous cardiac protective factors in diabetes rat.
其他文献
Our previous reseach show that Andrographolide (AP) has a protection on rats myocardial hypertrophy induced by isopropylarterenol (Iso), while its mechanisms about balance of vasoactive substance are
To observe the antioxidation and anti-inflammation effect of Genistein (Gen) on rats myocardial hypertrophy caused by isopropylarterenol (Iso).Methods: The myocardial hypertrophy model was formed thro
Abnormal arterial vasoconstriction is one of the major causes inducing post-flight orthostatic intolerance.It has been documented that Rho kinase (ROCK) could enhance the contraction of vascular smoot
Microgravity exposure may result in postflight orthostatic intolerance, which is associated with vascular remodeling.Nuclear factor κB (NF-κB) activation and increased inflammatory cytokines provide a
The aim of this study was to investigate whether decreased vasodilation in common carotid artery and abdominal aorta induced by hindlimb unloading (HU) is related with NADPH oxidase pathway.Arterial v
This study was designed to investigate the effects of 3-week simulated microgravity and intermittent artificial gravity on apoptosis of abdominal aorta smooth muscle cells (AASMCs) in rats.Hindlimb un
In vitro study has shown that activation of SK channels in the ventricular myocytes is responsible for the VF in failing ventricle.This study determined the role of SK channels in regulating VF in AMI
The calcium-activated chloride channels (CaCCs) are critical for many physiolo-gical functions.In cardiac tissues, CaCCs play important roles in the regulation of cardiac excitability.Although Anol (o
This study was to investigate whether Semen Cassiae extract reduces myocardial ischemia and reperfusion (MI/R) injury.Methods: The high-fat diet-fed streptozotocin (HFD-STZ) rat model (type 2 DM model
Background: Trauma induces not only primary heart injury but also secondary heart injury.Our previous study has demonstrated that mechanical trauma could cause cardiomyocyte apoptosis which contribute