In this study, flat sheet asymmetric polyphenylsulfone (PPSU) ultrafiltration membranes with enhanced antifouling properties were prepared by non-solvent induced phase separation (NIPS) method through compound additives containing polymeric pore-forming agent, small molecular non-solvent and surfactant.The formation processes of the porous asymmetric membranes with different kinds of additives were studied in detail, and the microstructure controllable preparation of membrane was achieved by establishing a bridge between the membrane preparation parameters and separation performances.All prepared membranes were characterized by using scanning electron microscope (SEM),contact angle analysis (CA), porosity, maximum pore size, water and BSA solution permeability studies.The performance efficiency of the membrane was evaluated by using BSA as a model foulant in terms of permeability, solute rejection (R),Rm (membrane inherent resistance), Rc (cake layer resistance), and Rp (pore plugging resistance).The results showed that when the compound additives were used, the inter-connected pores were observed, maximum pore size, contact angle and membrane filtration resistance decreased, while the porosity increased.When PVP compound additives were added, the water flux increased from 80.4 to 148.1 L/m2.h, the BSA rejection increased from 53.2 to 81.5%.Similar trend was observed for membranes added PEG compound additives, the water flux and BSA rejection simultaneously increased.The filtration resistance decreased as a result of compound additives.The uniformity of membrane and the number of effective pores could be enhanced by adding compound additives through cooperation of different additives.