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Background Resistance to standard Helicobacter pylori (H.pylori)treatment regimens has led to unsatisfactory cure rates in H.pyloriinfected patients.Quadruple therapies have been proposed in Maastrich Ⅳ as recommended treatment for H.pylori infection.This study was designed to evaluate efficacy of different bismuth-containing quadruple therapies for H.pylori eradication in first-line treatment.