Crystal Structure of 3WJ Core Revealing Divalent Ion-promoted Thermostability and Assembly of the Ph

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：chengyfei

【摘要】

：

【作者】

：

Hui Zhang James A.Endrizzi Yi Shu Farzin Haque Young-In Chi Peixuan Guo

【机构】

：

Nanobiotechnology Center,Markey Cancer Center and Department of Pharmaceutical Sciences,University o

【出处】

：

International Conference on Nanoscience & Technology,China 2

【发表日期】

：

2013年3期

【关键词】

：

RNA Crystal Metal ions 3-way junction RNA Nanotechnology RNA therapeutics

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　　Bacteriophage phi29 DNA packaging motor, one of the strongest biological motors constructed to date, is geared by a packaging RNA (pRNA) ring.The special properties of phi29 pRNA have led to the development of this RNA as a novel vehicle for applications in nanotcchnology and medicine.Recently, it has been found that the core structure of phi29 pRNA, a 54-m three-way junction (3WJ), exhibits extreme thermodynamic stability.

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Crystal Structure of 3WJ Core Revealing Divalent Ion-promoted Thermostability and Assembly of the Ph

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