Brefeldin A is a secondary metabolite of Ascomycetes species.It was first isolated in 1958 by Singleton from Penicillium decumbens1.
The Proton Pump Inhibitors(PPIs)are typical drugs for the management of peptic ulcer disorders[1-2].We carried extensively study on the synthetic process of the drugs,and gradually scaled up to manufa
Our early study showed that intraperitoneal administration of dauricine induced caused elevation of lactate dehydrogenase activity in brochoalveolar lavage in CD-1 mice.
Introducing new methods for mild and stereoselective glycosylation(Scheme 1): For O-glycosides,1)Using beta-pinene as acid scavenger,direct glycosylation of taxanes was rendered possible for the first
In all known synthetic routes[1-2] of dopexamine dihydrochloride(1),methyl protecting strategy was employed to protect phenolic hydroxyl group.The deprotection had to be carried out under harsh reflux
Histone deacetylases(HDACs)were reported as targets of anticancer drugs.It can silence tumor suppressor genes by the alteration of expression,leading to the occurrence of cancer[1].
人成纤维细胞生长因子受体(Fibroblast growth factor receptor,FGFR)是受体酪氨酸激酶(RTKs)超家族的主要成员之一。现已证实FGFR 对肿瘤细胞的生长和发展具有确切的促进作用。
肝癌严重的威胁着人类的生命健康,最新研究表明6-[3-(三氟甲基)苯基]哒嗪-3-(2H)酮类化合物具有良好的抗肝癌活性,尤以化合物YHHU-258活性最为显著[1,2]。本文以化合物YHHU-258作为先导化合物,设计并成功的合成了7个全新结构的哒嗪酮衍生物,并进行了抗肝癌活性研究,初步得到了化合物结构和活性之间的关系。