【摘 要】
:
Aim of the study: The purpose of this study was to determine the role of the Th 17/Treg shift in bone loss in estrogen deficient mice and to further elucidate the immunopharmacologic mechanism of ZGW
【机 构】
:
Institute of Basic Medicine, Shandong Academy of Medical Sciences,18877 Jingshi Road, Jinan 250062,
【出 处】
:
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Aim of the study: The purpose of this study was to determine the role of the Th 17/Treg shift in bone loss in estrogen deficient mice and to further elucidate the immunopharmacologic mechanism of ZGW in preventing bone loss induced by estrogen deficiency via regulating Th17/Treg paradigm.
其他文献
Background: Selenium (Se) nanomaterials have attracted increasing attention for their unique characteristics and potential applications in biological medicine.In recent years, considerable studies hav
背景和目的:肿瘤微环境中免疫负调控蛋白可诱导免疫效应T细胞凋亡并产生免疫逃逸,从而影响抗肿瘤效果.PD-1主要表达在活化的T细胞上,它与肿瘤中高表达的B7-H1结合,可诱导效应T细胞凋亡,是产生肿瘤免疫逃逸的重要分子.GM-CSF能促进DC成熟、分化及肿瘤抗原呈递,增强特异性的抗肿瘤免疫.为了能有效解除肿瘤免疫抑制信号又能诱导机体产生强的抗肿瘤免疫,如制备同时分泌PD-1中和抗体和GM-CSF因子
Backgroud: Hepatitis B virus (HBV) is one of the major causes of liver cirrhosis and hepatocellular carcinoma, and being a world-wide health concern, extensive fundamental and clinical researches have
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells which can differentiate into cells of the mesodermal lineage, such as osteoblasts, chondrocytes, adipocytes, fibroblasts,
研究背景:禽流感病毒不但给家禽养殖业造成了重大经济损失,同时也严重威胁着人类的健康,人们一直在研究各种形式的疫苗来应对禽流感病毒的危害,植物作为反应器,其具有成本廉价、保存运输方便、安全等诸多独特优点.目的:构建高效表达载体,以期表达禽流感基质蛋白胞外功能区2/霍乱肠毒素B亚基融合蛋白,研制可饲、廉价、安全的禽流感疫苗.方法:Genebank中查找目的基因序列,根据植物密码子偏好性进行基因改造,并
目的:精细解析幽门螺杆菌(Helicobacter pylori,Hp)尿素酶B亚单位(UreB)免疫小鼠后表位特异性CD4+T淋巴细胞的保护作用与应答机制. 方法:重组UreB抗原联合弗氏佐剂皮下免疫Blab/c小鼠,再以Hp菌株感染攻击建立免疫保护模型,流式细胞术分析免疫小鼠体内CD4+T淋巴细胞数量和增殖特性,Real-time PCR检测脾脏CD4+T淋巴细胞的IFN-r、IL-4和IL-
Highly pathogenic avian influenza A virus H5N1 continues to spread among poultry and has frequently broken the species barrier to humans.Recent studies have shown that a laboratory-mutated or reassort
Major histocompatibility complex (MHC) molecules bind short peptides derived from antigens and present them onto the surface of antigen-presenting cells (APCs) for T-cell receptor (TCR) recognition.Th
背景和目的:CML病人存在不同程度的T细胞免疫缺陷,为进一步了解CML病人T细胞活化信号分子TCRζ表达下调的调控因素,本研究分析TCRζ3端非编码区(3-UTR)基因多态性和突变情况,分析其对TCRζ基因表达水平的影响.方法:利用RT-PCR分别扩增20例CML病人的外周血单个核细胞(PMBCs)的TCRζ3-UTR,20例健康人外周血单个核细胞作为对照;采用SYBR Green Ⅰ染色荧光实时
Background: WT1126 (RMFPNAPYL) is a human leukocyte antigen-A2 (HLA-A2) restricted peptide derived from Wilms tumor protein (WT1), which is widely expressed in a broad spectrum of leukemias, lymphomas