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The article considers the optimum variable process control scheme for a process with incorrect adjustment.Incorrect adjustment of a process may result in shifts in process mean and variance, ultimately affecting the quality of products.For the process with incorrect adjustment, we construct the variable sampling interval (VSI) Z(X) and Z s2 control charts to control the process mean and variance with minimum loss.The performance of the minimum loss VSI control charts is measured by the average loss per unit time derived by Markov chain approach.An example of the metallic thickness of the connectors shows the application and performance of the minimum loss VSI Z(X) and Z s2 control charts in detecting shifts in mean and variance for the process with incorrect adjustment.Furthermore, the performance of the minimum loss VSI Z(X) and Z s2 control charts and the loss of fixed sampling interval Z (X) and Z s2 control charts are compared by some numerical analysis results.These demonstrate that the former outperforms in detecting small to large shifts in mean and variance.