穿心莲总内酯固体脂质纳米粒处方工艺的星点设计-效应面法优化

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：guoliangc

【摘要】

：

【作者】

：

Tao YANG Huan-huan SHENG Yan LI Xue-mei CHENG Zheng-tao WANG Chang-hong WANG

【机构】

：

Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,The MOE Key

【出处】

：

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

：

2012年10期

【关键词】

：

Andrographis Paniculata Total lactones from Andrographis Solid Lipid Nanoparticl

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　　Objective:To establish a method for simultaneously determination of drug loading and entrapment efficiency of total lactones from Andrographis Paniculata loaded solid lipid nanoparticles (TLA-SLN),and to optimize the formula of TLA-SLN.Methods:The free drugs in TLA-SLN were separated by ultrafiltration along with HPLC assay for AND、NEO、DEO and DEH.The separation was performed on a Kromasil C18 column (150 mm × 4.6 mm,5μm) with mixture of acetonitrile-water (30 ∶ 70) as the mobile phase and with column temperature at 35 ℃.

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穿心莲总内酯固体脂质纳米粒处方工艺的星点设计-效应面法优化

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