【摘 要】
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Faithful tracking of rapidly successive acoustic signals in the primary auditory cortex(A1)is vital for processing temporal information and perception of natural sounds such as human speech and animal
【机 构】
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Department of Biomedical Engineering,School of Medicine,IDG/McGovern Institute for Brain Research,Ts
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Faithful tracking of rapidly successive acoustic signals in the primary auditory cortex(A1)is vital for processing temporal information and perception of natural sounds such as human speech and animal vocalizations.However,how cortical stimulus-tracking capacity developmentally emerges remains poorly understood.Using in vivo whole-cell recordings,we found that inhibition in the developing rat A1 was initially prolonged and strong,leading to cortical responses with considerably poor temporal resolution.Unexpectedly,exposure to repeated acoustic stimulation produced significant and long-lasting shortening of inhibition duration and moderate decrease of inhibition to excitation(I:E)ratio,resulting in strongly improved periodicity of cortical responses.Selective interruption of the signaling pathway of postsynaptic GABAB receptors improved cortical stimulus-following ability and prevented exposure-induced plasticity.Furthermore,blockade of N-methyl-D-aspartate(NMDA)receptors abolished the exposure effects.These results identified the GABABR as a key player in NMDA receptor-dependent,non-map plasticity of temporal processing in the developing A1.
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