2. 您的位置
3. 首页
4. 会议论文
5. Toll-Like Receptor-4/p38 Mitogen-Activated Protein Kinase (MAPK) Signaling in the Dorsal Horn Partia

Toll-Like Receptor-4/p38 Mitogen-Activated Protein Kinase (MAPK) Signaling in the Dorsal Horn Partia

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：wangliang19910125

【摘 要】

：

Background: Our previous research suggested that the microglial P2X4 purinoceptor (P2X4R) is involved in the activation of toll-like receptor-4 (TLR4) and the release of brain-derived neurotrophic fac

【作 者】

：

Li-Na Wang Jian-Ling Zuo Si-lan Liu Xiao-Hong Jin Michael Namakad Jian-ping Yang 

【机 构】

：

Department of Anesthesiology, The First Affiliated Hospital of Soochow University,Suzhou City, Jiang

【出 处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年9期

【关键词】

：

cancer induced bone pain toll-like receptor-4 P2X4 purinoceptor phosphorylated-p 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Background: Our previous research suggested that the microglial P2X4 purinoceptor (P2X4R) is involved in the activation of toll-like receptor-4 (TLR4) and the release of brain-derived neurotrophic factor (BDNF) leading to the induction of cancer induced bone pain (CIBP).

其他文献

The mechanisms and functions of ATP-induced P2X3 receptor trafficking in primary sensory neurons

The purinergic (P)2X3 receptor, an ATP-gated ion channel, plays a vital role in sensory processing and transmission.The assembly and trafficking of P2X3 receptor are important for its function in prim

会议

P2X3 receptorATPreceptor traffickingprimary sensory neuron

Facilitated corticospinal projecting neurons after peripheral nerve injury

Long term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain.In case of persistent chronic pain, peripheral injury triggered LTP in the spinal co

会议

LTPanterior cingulate cortexGluA1pain

Is Acid Painful?

Acid (or proton) is an effective algogen to excite nociceptors and evoke pain.Is acid really painful? For patients who suffer with arthritis, fibromyalgia, myofascial pain, etc., the answer is definit

会议

Adrenergic z-receptor mediates itch hypersensitivity following heterotypic chronic stress in rats

Chronic stress is widely considered to trigger or enhance itch, especially for pruritic dermatitis.However, the molecular mechanisms linking chronic stress and itch are still unknown.The present study

会议

Chronic stressItchSympathetic nervous systemAdrenergic receptors

Differential roles of parabrachial nucleus in pain and itch

Spinal cord projection neurons mainly target the parabrachial nucleus, which could be important in pain and itch signal processing.However, the synaptic property and functional role of this projection

会议

Taming serotonin outflow and inflammatory colonic hyperalgesia by blocking Ih channels in enterochro

Treatment of Crohns disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel diseases (IBD), has been a major clinical challenge, whereas the incidence of IBD has been on the

会议

Presynaptic cyclic GMP-dependent protein kinase I in nociceptors is a key determinant of spinal syna

Chronic pain represents a major challenge to clinical practice and basic science.Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery

会议

Presynaptic PKG-Ispinal LTPpain hypersensitivity

Peripheral pain is enhanced by insulin-like growth factor 1 through a G rotein-mediated stimulation

Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain)sensitivity of primary afferent neurons.We found that the IGF-1 receptor (IGF-1R)functionally stimulated voltage-gated T-typ

会议

New mechanisms of metastatic bone cancer pain: cancer tissue-derived ENDOGENOUS formaldehyde activat

In recent years, our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain.We found that cancer cells produced formaldehyde through demethylatio

会议

Bone cancer painFormaldehydeTransient receptor potential vanilloid subfamily m

Ozone interventional composite therapy for intractable PHN of irritable nociceptor type, the result

Objective Neuropathic pain (NP) is a complex, chronic painful disease and most of them are still an intractable painful disease of worldwide even at present.Post-herpetic neuralgia (PHN) is one of typ

会议