【摘 要】
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We described herein the total synthesis of the structurally complex natural products(+)-gelsemine4 and(+)-harringtonolide.5 It was shown that(+)-gelsemine has potent and specific antinociception in ch
【机 构】
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State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China;Guangdong
论文部分内容阅读
We described herein the total synthesis of the structurally complex natural products(+)-gelsemine4 and(+)-harringtonolide.5 It was shown that(+)-gelsemine has potent and specific antinociception in chronic pain.3(+)-harringtonolide was shown to inhibit the growth of tobacco and beans.2 In addition to antineoplastic and antiviral activities,(+)-harringtonolide was found to have potent cytotoxic activities with IC50 = 43 nM for KB tumor cells and to cause necrosis under some conditions.1 Owing to their intriguing architecture and outstanding biological activities,(+)-gelsemine and(+)-harringtonolide attracted our attention.
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