Experimental studies reveal that the pathogenesis of neurogenic inflammation involves an activation of spinal cord GABAergicinterneuronal circuits where action potentials are generated and then propag
多囊肾瞬时电位受体TRPP2(也称为PKD)在约15％的常染色体显性多囊肾病(ADPKD)发现有基因突变.TRPP2的突变还与除肾脏以外其他疾病紊乱的临床表现相关，如肝脏胰腺的囊肿，脑动脉瘤，胚胎左右极异常发育及视网膜的功能等.TRPP2存在于脑及视网膜中，但其生理作用及功能很大程度上仍未知，由于过多或多少的TRPP2都会导致疾病的发生，因此对阐明TRPP2表达的调节机制是非常重要的.
干细胞移植提供了治疗脑卒中的再生医学，并在动物实验中显示出多种治疗效果。另一方面，干细胞移植治疗神经系统疾病还处于早期的实验阶段。许多问题还毋须解决。本演讲将重点介绍近年来在干细胞移植中结合其它神经保护和分子调控机制达到提高移植细胞的存活，迁移能力和促进再生功能的疗效。
前扣带回皮质(ACC)是脑边缘系统的重要组成部分，在慢性痛的发生、发展和调控中发挥重要作用。以往的研究认为ACC通过激活脑干的5-HT能下行疼痛调控系统参与伤害性信息的调控，而ACC直接到脊髓背角(SDH)的调控通路则未见报道。本研究综合利用了形态学、分子生物学，电生理学等的方法发现：ACC的V层椎体细胞向脊髓背角直接投射。
In current drug discovery pipeline, in vitro biochemical and cell-based screening assays have been widely used before the pharmacological validation tests on in vivo animal models.Nevertheless, the lo
杜氏肌营养不良症是一种X连锁隐形遗传性疾病,大约3,600个男孩中就会有1个患者。临床特点为进行性对称性肌无力,通常在12岁左右失去行走能力,二十几岁死亡。目前临床上尚无法治愈。本讲演将讨论治疗新进展,有些疗法已经在临床上试用,有的还尚在研究中,这些新疗法给杜氏肌营养不良症带来了希望,甚至有治愈的可能。
Chronic neuropathic pain is a common and debilitating consequence of spinal cord injury (SCI).In a rat contusion injury model, we observed that chronic neuropathic pain is present on day 7 after SCI a
Suppressor Of Cytokine Signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway.SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling and inflammatory gene expre
Introduction: The main characteristic of the heat stress response is activation of hypothalamicpituitary-adrenal (HPA) axis, which will promote body to produce cortieotropin releasing hormone (CRH), c
Introduction: The hypothalamic-pituitary-adrenal axis is a key component of the acclimatory response to stress, resulting in the release of stress hormone (CRH)、 cortisol (Cor、 (EPI) and (HSP).CRH can