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Purpose The present study examined the effects of gender,age,height,weight,Body Mass Index(BMI),lumbar spine bone mineral density(LSBMD),femoral neck bone mineral density(FNBMD),Serum calcium(Ca),Serum phosphorus(P),Serum alkaline phosphatase(ALT),and Serum vitamin D(VitD)on tumorigenesis in osteoporosis patients and the incidence of osteoporotic fracture in relation to age in middle-aged and elderly.