Hypocrellin A (HA) and hypocrellin B (HB), have been well recognized to be efficient photodynarnic agents against many tumor cell lines and viruses.Nevertheless, the poor aqueous solubility and the low absorbance in phototherapeutic window (600-900 nm) hamper their clinical applications, which in turn has driven the synthesis and investigation of chemically modified hypocrellins.Recently, we prepared a complex of HA with lanthanum ion (La3+-HA),to our surprise, which shows higher 1O2 quantum yield than the parent HA [1, 2].La3+-HA also exhibits longer triplet excited state lifetime over HA and larger electrostatic attraction with DNA, and thus higher photodamage capability on calf thymus DNA (CT DNA).In this work,15 complexes of HA with rare earth trivalent ions (except Pm3+) along with the complex of HA with Sc3+ were prepared, and their photodynamic activities, including absorption in phototherapeutic window (600-900 nm), water-solubility, triplet lifetime, generation of reactive oxygen species (ROS), affinity to DNA, as well as photodamage on CT DNA, were compared in detail.