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The ability to sense and detect ultra-low concentrations of specific DNA sequences using simple and inexpensive assays is important in clinical diagnostics,mutation detection,and biodefense applications.Here we report a homogeneous,colorimetric detection of single-stranded DNA sequences,based upon nicking endonuclease-assisted nanoparticle amplification.The detection system offers a colorimetric detection limit of 0.5 fmol within hours for selected oligonucleotides.