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  5. Role of all-trans retinoic acid in preventing ischemia/reperfusion injury in aldose reductase transg

Role of all-trans retinoic acid in preventing ischemia/reperfusion injury in aldose reductase transg

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户：davidzn
【摘 要】
：
Background All-trans-retinoic acid (ATRA) has been shown to posses the function of preventing cell death in various tissues undergone ischemia/reperfusion (I/R) injury.ATRA expression could be cut dow
【作 者】
：
Zhu Zhengbin Zhao Xiaoran Zhu Jinzhou Lu Lin Shen Weifeng Zhang Ruiyan 
【机 构】
：
Department of Cardiology,Rui Jin Hospital,School of Medicine,Shanghai Jiao Tong University
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
【发表日期】
：
2014年3期
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Background All-trans-retinoic acid (ATRA) has been shown to posses the function of preventing cell death in various tissues undergone ischemia/reperfusion (I/R) injury.ATRA expression could be cut down in the presence of Aldose reductase (AR) which has been recognized as a key role in increasing cardiac I/R injury,especially in diabetes.Our objectives were to investigate the contribution of ATRA down regulation conducted by AR in cardiac I/R injury and that of ATRA supplement in cardiac I/R injury.
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