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Background & Aims Increased KCNJ 15 expression has been found in patients with hepatitis B virus (HBV)-induced Acute-on-chronic liver failure (HBV-ACLF) in previous gene microarray study.However,the mechanism underlying the enhanced expression of KCNJ15 in patients with HBV-ACLF remains unclear.In this study,we further investigate the up-regulated KCNJ 15 and its possible regulatory mechanisms in HBV induced liver injury.Methods The expression of KCNJ 15 was studied in patients with HBV-ACLF on both mRNA and protein levels in peripheral blood mononuclear cells (PBMC) and liver tissue,while the function of KCNJI5 was further determined in Jurkat cells in vitro by transfection of a human KCNJ15 expression plasmid.