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OBJECTIVE: To explore the incidence, pathogenetic and risk factors of acute kidney injury (AKI) in the very elderly patients with mechanical ventilation (MV).METHODS: A total of 260 elderly patients with MV in the geriatric department of Chinese PLA General Hospital from January 2008 to December 2012 were enrolled.Their clinical data were analyzed to explore the incidence and risk factors of acute kidney injury (AKI) in the very elderly patients after MV.