【摘 要】
：
Pyrazole cycle frequently exists in bioactive molecules.In order to discover antimicrobial lead compounds with novel chemical scaffold, fourteen novel 3-trifluoromethyl-1,4-pyrazole diamide derivative
【机 构】
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Key Laboratory of Natural Pesticide and Chemical Biology of the Ministry of Education, South China A
【出 处】
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第二届生物农药理论探索及产业化技术创新研讨会
论文部分内容阅读
Pyrazole cycle frequently exists in bioactive molecules.In order to discover antimicrobial lead compounds with novel chemical scaffold, fourteen novel 3-trifluoromethyl-1,4-pyrazole diamide derivatives were designed and synthesized.All the compounds were clearly characterized by 1H, 13C NMR, ESI-MS spectroscopy and elemental analysis.The results of antimicrobial activity showed that compounds 6a7 and 6b7 exhibited moderate antifungal against rice sheath blight (Rhizoctonia solani) while compound 6a5 and 6b5 which emerged potent antibacterial against rice bacterial leaf blight (Xanthomonas oryzae) could be the potential candidates for new antibacterial agents.
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