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  5. Catechol-grafted dendrimer with a neutral shell allows pH-triggered “off-on” release of bortezomib

Catechol-grafted dendrimer with a neutral shell allows pH-triggered “off-on” release of bortezomib

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：lanqin2394
【摘 要】
：
pH-responsive drug delivery systems can retain the drug within the carrier and release it under mild acidic conditions [1].They improve the therapeutic efficacy and decrease the side effects of antica
【作 者】
：
Mingming Wang Yu Wang Naimin Shao Jianru Xiao Yiyun Cheng 
【机 构】
：
Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University,S
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
dendrimer bortezomib catechol pH responsive off-on 
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　　pH-responsive drug delivery systems can retain the drug within the carrier and release it under mild acidic conditions [1].They improve the therapeutic efficacy and decrease the side effects of anticancer drugs during chemotherapy.Bortezomib (BTZ) is an efficient anticancer drug in the treatment of various cancers,however,it is usually criticized for serious side effects [2].Numerous drug carriers were designed to deliver BTZ in the past decade,but few of them can realize "off-on"release of BTZ in tumor tissues [3].
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