【摘 要】
：
OBJECTIVE To detect whether YL-IPA08, a new TSPO ligand designed and synthesized by our institute, may be effective in the treatment of PTSD.METHODS We first assessed the effects of YL-IPA08 in allevi
【机 构】
：
Department of New Drug Evaluation, Institute of Pharmacology and Toxicology, Academy of Military Med
【出 处】
：
第十六届全国神经精神药理学学术会议
论文部分内容阅读
OBJECTIVE To detect whether YL-IPA08, a new TSPO ligand designed and synthesized by our institute, may be effective in the treatment of PTSD.METHODS We first assessed the effects of YL-IPA08 in alleviating the enhanced anxiety and fear response induced in the inescapable electric foot shock-induced mouse model of PTSD and the time-dependent sensitization (TDS) procedure, a rat PTSD animal model.In an effort to explore the role of TSPO in mediating the antiPTSD effect of YL-IPA08, we then tested whether blocking the TSPO ligand with a TSPO antagonist, PK11195;either alone or in combination with YL-IPA08 treatment,affected the behavioral effect of YL-IPA08 in post-TDS rats.Furthermore, the changes of Allo in the serum and prefrontal cortex after chronic YL-IPA08 administration were also assessed in TDS-treated rats.RESULTS In the present study, we showed that chronic treatment with YL-IPA08 caused significant suppression of the enhanced anxiety and contextual fear induced in the inescapable electric foot-shock induced mouse model of PTSD and the TDS procedure in rats; these effects were completely blocked by the TSPO antagonist PK11195.Furthermore,YL-IPA08 treatment increased the levels of Allo in the prefrontal cortex and serum of post-TDS rats and these effects were antagonized by PK11195.CONCLUSION In summary, the findings from the current study showed that YL-IPA08, a potent and selective TSPO ligand, had a clear anti-PTSD-like effect, which might be partially mediated by binding to TSPO and the subsequent synthesis of allopregnanolone.
其他文献
Objectives: To investigate the prevalence of deciduous caries in 3～4 years in urban and rural areas, and analyze its influencing factors.Methods: 886 children aged 3 to 4 selected from Changchun city
Objectives: To investigate caries status of primary and permanent teeth among children aged 8 to 9 years in Guangzhou Baiyun District, and correlation between caries of primary molars and first perman
Dental caries is an infectious disease most commonly occurs in children.Dental caries in childhood, often called Early Childhood Caries (ECC) is a health problem that the highest prevalence.ECC is als
The etiology of severity of periodontal disease is multifactorial, such as plaques,systemic disease, hormonal, and other environmental factors which have responsible for periodontal disease.In other s
Objectives: Oral sugar is metabolized pyruvate, and the pyruvate are converted to various organic acid lactic acid, acetic acid, and formic acid causing dental caries by oral bacteria (Streptococci mu
Sleep disturbance is closely associated with chronic pain.Given the bidirectional relationship between pain and sleep, treatment must focus on alleviation of both the pain and sleep disturbance.Paeoni
OBJECTIVE To explore the relationship between hyperpolarization-activated cyclic nucleotidegated channels (HCN) and the comorbid neuropathic pain and mental disorder.METHODS Rat spared nerve injury (S
目的 探讨抗癌止痛肽(AGAP)的止痛作用机制，考察了其镇痛作用是否与调节钠离子通道相关，以期为阐述抗癌止痛肽的镇痛作用与机制提供理论依据。方法 应用原代培养和急性分离的方法获得大鼠背根神经节(DRG)神经元，应用MTT法考察AGAP对大鼠DRG神经元存活率的影响；采用膜片钳全细胞记录模式结合分子生物学实验考察抗癌止痛肽的镇痛作用的离子通道机制。结果 实验结果表明，抗癌止痛肽对原代培养和急性分离的
烟碱型乙酰胆碱受体(nAChR)是由5个亚基组成的五聚体跨膜蛋白,分为肌肉型和神经型两大类,其中神经型nAChRs异常复杂,它们由不同的α和β亚基组成异源或同源型的功能性受体亚型,在脊椎动物中,至少有12个亚基,即α2～α10,β2～β4.虽然这些亚型的药理学功能截然不同,但其结构非常相似,极难区分,以致各个亚型的生理功能和药理学作用至今尚不清楚.发现和开发各个亚型的特异性分子探针,将有利于揭示和
目的 探讨FKBP5是否参与糖皮质激素介导的抑郁样行为的发生。方法 分别采用慢性轻度应激(CMS)和皮下注射皮质酮40 mg· kg-1诱导抑郁大鼠模型；行为学采用强迫游泳实验、糖水偏好实验、新奇觅食潜伏期实验、高架十字迷宫检测大鼠的无助绝望、兴趣缺失抑郁样行为和焦虑样行为；ELISA法检测大鼠血浆中糖皮质激素的水平；Western blot检测大鼠海马和额前皮质中FK506结合蛋白51(FKBP