【摘 要】
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To Prepare puerarin phospholipid complex, optimize their preparation process and improve the physicochemical properties of puerarin.Methods Using single factor and orthogonal design method to screen t
【机 构】
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Department of Pharmacy,the Second Xiangya Hospital of central south university,Hunan Changsha 410011
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
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To Prepare puerarin phospholipid complex, optimize their preparation process and improve the physicochemical properties of puerarin.Methods Using single factor and orthogonal design method to screen the optimal preparation process of puerarin phospholipid complex, and using X-ray diffraction analysis to identify puerarin phospholipid complex.Results The optimal prescription of puerarin phospholipid complex is: ethanol as the reaction solvent, the ratio of puerarin to soyabean phospholipids is 1:1.5 (m: m), the concentration of puerarin is 20mg/ml, then reacting l h at 40℃.X-ray diffraction analysis shows that puerarin phospholipid complex differs from the physical mixture of puerarin and soybean phospholipids.Conclusion The preparation of puerarin phospholipid complex is not the simple physical mixing process, but by certain chemical effect.
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