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  5. Bi-directional modulation of neuronal excitability by TRPC4-containing channels in mouse lateral sep

Bi-directional modulation of neuronal excitability by TRPC4-containing channels in mouse lateral sep

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：weilonglee
【摘 要】
：
In the central nervous system, canonical transient receptor potential (TRPC) channels have been implicated in mediating neuronal excitation induced by stimulating metabotropic receptors, including gro
【作 者】
：
Jinbin Tian Dhananjay P.Thakur Michael X.Zhu 
【机 构】
：
University of Texas Health Science Center at Houston, USA
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
TRP channels neuronal excitability calcium metabotropic glutamate receptors depo 
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In the central nervous system, canonical transient receptor potential (TRPC) channels have been implicated in mediating neuronal excitation induced by stimulating metabotropic receptors, including group 1 metabotropic glutamate receptors (mGluRs).However, to what extent native TRPC4-containing channels (TRPC4-cc) are activated as well as the impact of TRPC4-cc activations at different levels on neuronal excitability remain elusive.
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