Two-dimensional chromatography had become an important analytical tool for the separation of complex samples.The development of two-dimensional high-performance liquid chromatography which mainly used valves as interface to switch the components between the first dimension and the second dimension had matured, while two-dimensional ion chromatography was rarely reported which used valves to eliminate the matrix.Two-dimensional ion chromatography subjected to many factors such as specific mobile phase (acid and alkali) and special construction of suppresser, developed slowly.