Lung cancer( LC) is the leading cause of cancer mortality,with more than I million deaths worldwide every year.Early and accurate detection of cancer permits effective intervention,which facilitates efficacious therapy and monitoring of therapeutic progression.and can reduce mortality and morbidity.However,conventional diagnostic methods,such as chest X-ray,computed tomography ( CT),magnetic resonance imaging ( MRI),and positron emission tomography ( PET)[l],are unsuitable for widespread screening because they are time-consuming,expensive,and.furthermore,occasionally miss tumours.Additionally,the technologies associated with these approaches are unavailable in many medical facilities and require relatively large amounts of tissue for analysis.The development of new point-of-care diagnostic strategies with sufficient sensitivity and specificity for early cancer detection is always being sought for disease diagnosis and severity grading. Surface-enhanced Raman spectroscopy ( SERS )[2],with its molecular specificity,multiplexing capabilities and various signal enhancement techniques for increased sensitivity,has emerged as an excellent analytical tool for multiparameter molecular analyses,which offer the potential for early diagnosis.Herein,we have fabricate a unique 3D Au@ MOF nanocomposite array for noninvasive and easy-to-use LC diagnostic,which exhibit an improved plasmon resonance effect that dramatically increases the Raman scattered light emitted by biomarkers enriched inside their encapsulated MOF.