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5. Discovery of efficient siRNA carriers in a library of alkylated,cycloalkylated and fluoroalkylated p

Discovery of efficient siRNA carriers in a library of alkylated,cycloalkylated and fluoroalkylated p

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：bassdd

【摘 要】

：

Cationic polymers are usually constrained by relatively low transfection efficacy or serious toxicity in siRNA delivery[1].Alkylation was reported to be an efficient strategy to improve the performanc

【作 者】

：

Wanwan Shen Hui Wang Yiyun Cheng 

【机 构】

：

Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University,D

【出 处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

hydrophobic modification fluorination bPEI structure-fuction relationship 

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　　Cationic polymers are usually constrained by relatively low transfection efficacy or serious toxicity in siRNA delivery[1].Alkylation was reported to be an efficient strategy to improve the performance of cationic polymers[2].

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