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Objective The betweenness centrality as a measure was first introduced to evaluate the role or the position of nodes in the network.It measures the probability of a node that appear in the shortest path between other nodes and it indicates the ability of the node as an information hub in the entire network.Here,we used DTI tractography and graph theoretical approaches to compare the differences of the betweenness centrality of the nodes in the brain structural networks of the depression and the healthy.