【摘 要】
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A transcription factor known as cyclic AMP response element-binding protein has been shown to be involved in the central sensitization in neuropathic pain and inflammation pain.The present study exami
【机 构】
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Department of Anatomy and K.K.Leung Brain Research Centre, The Fourth Military Medical University, X
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
A transcription factor known as cyclic AMP response element-binding protein has been shown to be involved in the central sensitization in neuropathic pain and inflammation pain.The present study examined the roles of cyclic AMP response element-binding protein and of the phosphorylated cyclic AMP response element-binding protein in the maintenance of mechanical and cold allodynia induced by a neuropathic pain model,"spared nerve injury," in rats.First,the results of immunohistochemical study showed that phosphorylated cyclic AMP response elementbinding protein,but not cyclic AMP response element-binding protein,increased bilaterally in the spinal dorsal horn 14 days following spared nerve injury,indicating a possible contribution of phosphorylated cyclic AMP response element-binding protein in spared nerve injury.
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