Objective: To evaluate the effects of distraction osteogenesis in management of oral and craniomaxillofacial anomalies.Methods: Retrospective cohort study at our hospital of patients with oral and craniomaxillofacial anomalies diagnosed as midface deficiency, facial asymmetry and temporomandibular joint ankylosis patients with obstructive sleep apnoea, (Pierre Robin sequence) from March 2006 to December 2013.Preoperatively the patients were worked up for cephalometric and CT scans, and PSG for the OSAHS.Rigid extemal or intemal distraction devices were individually selected with respect to optimal stability during active distraction and consolidation phase.Distraction osteogenesis was followed with 4-7 days latency period.Rate of distraction was 1 mm/day.After 3 months post distraction assessment was done using cephalometric and CT scan.Pierre Robin sequence was also accessed polysomnography.TMJ ankylosis released by gap arthroplasty or reconstruction after distraction osteogenesis.Additional reconstructive or orthognathic surgery was conducted for part of patients in this group despite successful distraction to get ideal aesthetic or functional results.