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目的 Thestudyaimstoexplorethemolecularbasisforthepoorresponseofepithelialgrowthfactorreceptortyrosinekinaseinhibitors(EGFR-TKIs)inEGFRmutatednon-smallcelllungcancer(NSCLC)patientswithsmokinghistory.NovelagentovercomingEGFR-TKIresistancehadalsobeeninvestigated.