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Background and aims Enterocutaneous fistulas (ECF) are one of the most devastating abdominal complic ations described in the practice of surgery.A single nucleotide polymorphism in heat shock protein 70-2 (HSP70-2) has been shown to be associated with a penetrating behavior in some disease.The purpose of this study was to identify associations between the HSP70-2 polymorphism and the clinical courses of enterocutaneous fistulas in the Chinese population.