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Sweet Sorghum is a potential energy plant due to its abilities of fast growth and high biomass.It is beneficial to improve the efficiency of energy transformation by controlling lignin contents in plants.4-coumaric acid coenzyme A ligase (4CL) is a key rate-limiting enzyme in the biosynthesis of lignin.Seven 4CL-like proteins in sorghum were found by homolog blast in NCBI plant database.