【摘 要】
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The concept of cancer stem cells (CSCs) is becoming a fascinating research area leading to a revision of the conventional chemotherapic approach.In vitro culture in unattached conditions where cells g
【机 构】
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Biomaterials Lab Chemistry, Materials and Chemical Engineering Department Politecnico di Milano Ital
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The concept of cancer stem cells (CSCs) is becoming a fascinating research area leading to a revision of the conventional chemotherapic approach.In vitro culture in unattached conditions where cells grow in round balls called spheres is routinely used for enrichment and propagation of stem cells.To maintain their "stemness" and preclude their differentiation to the bulk tumor, the nonadherent conditions for in vitro test of CSCs are requested.The goal of our study was to design suitable poly (ethylene) glycol (PEG)-based hydrogel matrices and explore their potentiality as nonadherent substrates for in vitro study of CSCs.
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