Unimer polyion complex self-assembled nanomicelle for systemic delivery of siRNA into solid tumor

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户:inspisee1999
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  For successful RNAi-based cancer therapy,a safe and efficient siRNA delivery system is needed[1].Here,we report a novel approach for preparation of a stable nanomicelle derived from unimer polyion complexes for delivery of siRNA into solid tumors.
其他文献
Silk fibroin from silk worms (B.mori) is a naturally-rich protein polymer at a low cost.With intrinsic unique properties,it has been widely explored as various kinds of biomedical materials for cell c
Drug-resistance has been a major challenge for the failure of chemotherapy.Nitric oxide (NO) as a P-glycoprotein inhibitor can reverse the resistance to antineoplastics by inhibiting drug efflux[1].Ap
Development of effective gene vectors is critical to the success of gene therapy[1].Up-to-date,readily-available gene vectors are limited due to their inefficiency,cytotoxicity and poor targeting capa
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal human cancer with a poor prognosis and a 5-year survival rate of less than 7%.In recent years,the roles of fibroblasts in PDAC microenvironme
Dendrimer entrapped metal nanoparticles (M-DENs) are widely studied for their potential applications in catalysis,drug delivery,photophysics,diagnosis and sensing.The high level of control over the ar
The medicinal capsules offer better solid dosage form for drugs with low compressibility,slow dissolution and bitter tasting,and require disintegration in stomach as rapid as possible in the most case
Creatinine is a typical low molecular uremic toxin which accumulates in the bodies of chronic renal failure (CRF) patients and then produces toxic effect[l].The clearance of creatinine is of great imp
Although current cancer therapy enables complete cure for a certain percentage of patients,there are still many obstacles that have to be overcome in order to further improve the overall outcome.
Thermo-triggered drug release systems are widely used as drug carriers.Nevertheless,complicated carrier materials are required and their temperature response ranges are difficult to control[1].
Gemcitabine (GEM) is the most potent anti-cancer drug for the treatment of pancreatic cancer.However,it undergoes rapid deamination in the bloodstream and becomes biologically inactive.